Amounts tested in animals or volunteers
TB-500 dosage studies don't give you a treatment plan
Can the tested amounts guide your treatment? They can't give you a safe personal plan. Most studies used animals or gave people a different substance.
The short answer is that animal amounts aren't your treatment
Why can't you copy these study amounts? Most tests gave thymosin beta-4 instead of TB-500. Your own injury wasn't the reason those amounts were chosen.
Stroke-study rats got belly injections [4].
A muscle-disease study treated mice with 150 micrograms twice weekly. Micrograms measure weight in millionths of one gram. Researchers treated those mice for six months with thymosin beta-4.
Your body wasn't tested with that animal plan.
The human study you may hear about gave the larger protein through a vein. It tested 42, 140, 420, and 1260 milligrams. Volunteers first received a single treatment. They later received daily treatment for 14 days.
Phase 1 means an early check for harmful effects [6].
Cells in dishes responded to much smaller amounts. Just 10 picograms helped skin cells move [3]. A picogram is a weight far below a grain of salt. Tiny amounts of thymosin beta-4 also activated hair-root cells [7].
Your injury doesn't have a tested amount from those findings.
People discussing personal research use describe starting with more. They later use less to try to keep an effect. Trials of treatment in people haven't checked those schedules.
The rat stroke results challenge the idea that more helps.
At 18 milligrams per kilogram, rats showed no clear benefit. Rats improved at 2 and 12 milligrams per kilogram [4]. The weight is each rat's body weight, rather than yours.
A smaller substance can't take the larger protein's place
The same weight doesn't give you the same treatment. A dalton measures weight too tiny for you to see. Each thymosin beta-4 molecule, one whole unit of that protein, weighs about 4963 daltons.
Each TB-500 molecule weighs about 889 daltons [5].
The smaller substance weighs roughly a fifth as much. So an equal weight holds more of the smaller molecules. You can picture equal weights of large and small pieces. The smaller pieces are more numerous.
More pieces don't mean more repair in your body.
The shorter substance lacks parts of the whole protein [5]. The missing parts may affect your body differently. Researchers haven't shown equal repair effects from the two substances.
Weight alone can't supply a safe treatment amount.
Skin-cell tests used tiny amounts directly near cells in dishes [3]. Hair-root tests also measured changes near the cells [7]. Those tests didn't follow the substance through your blood or organs.
Your blood and organs make a different setting.
The Phase 1 safety study gave people thymosin beta-4 [6]. No human comparison establishes a healing amount for the shorter substance [5]. Your doctor can't calculate proven benefit from these weights.
You need the actual treatment tested in people.
How treatment was given differs from personal research shots
Researchers gave many animals injections into the belly. That was how the stroke-study rats received treatment [4]. People in the Phase 1 safety study got thymosin beta-4 through a vein [6]. You'll also find vein treatment in some heart tests.
Skin and eye tests placed treatment on the surface.
The larger protein was made into RGN-259 for eye studies [12]. Giving treatment those ways didn't test the shorter substance. Your body can respond differently depending on how treatment enters.
For personal research use, people describe muscle shots or shots under skin.
Those accounts aren't comparisons between treated and untreated groups. Calling your own use research doesn't create such a study. You can't tell if the chemical caused the change described.
You also need to know what was in the bottle.
The research substance comes as dried powder. Freezing, thawing, and breakdown inside the body can damage the chemical. A bottle may contain the wrong substance or unwanted material.
A person's shot may differ from the substance researchers tested.
TB-500 doesn't have a proved timetable for your recovery
No study establishes how fast TB-500 heals your injury. Thymosin beta-4 helped rat wounds grow new skin. At 4 days, treated wounds had 42% more new skin than salt-water comparisons.
The difference reached up to 61% at 7 days [3].
Your healing time can't be read from those rat results.
How long the shorter substance stays in your blood isn't known
How long does TB-500 stay in your blood? Human tests haven't answered that. Phase 1 researchers tested thymosin beta-4 instead. Higher amounts left more of that protein in the blood [6].
The protein's blood level fell to half the starting level more slowly after higher amounts.
The available details don't say how much longer. That result doesn't give you a time for TB-500. Horse tests detect the substance and remains after breakdown.
Finding remains doesn't tell you how long treatment works.